Membrane-Type Matrix Metalloproteinases Cleavage of Focal Adhesion Kinase in Vascular Smooth Muscle Cells Overexpressing
نویسندگان
چکیده
Tomoko Shofuda, Ken-ichi Shofuda, Nicola Ferri, Richard D. Kenagy, Elaine W. Raines and Membrane-Type Matrix Metalloproteinases Cleavage of Focal Adhesion Kinase in Vascular Smooth Muscle Cells Overexpressing Print ISSN: 1079-5642. Online ISSN: 1524-4636 Copyright © 2004 American Heart Association, Inc. All rights reserved. Greenville Avenue, Dallas, TX 75231 is published by the American Heart Association, 7272 Arteriosclerosis, Thrombosis, and Vascular Biology doi: 10.1161/01.ATV.0000126680.78500.4c 2004;24:839-844; originally published online March 25, 2004; Arterioscler Thromb Vasc Biol. http://atvb.ahajournals.org/content/24/5/839 World Wide Web at: The online version of this article, along with updated information and services, is located on the http://atvb.ahajournals.org/content/suppl/2004/05/05/24.5.839.DC1.html Data Supplement (unedited) at:
منابع مشابه
Cleavage of focal adhesion kinase in vascular smooth muscle cells overexpressing membrane-type matrix metalloproteinases.
BACKGROUND Membrane-type matrix metalloproteinases (MT-MMPs) were initially identified as cell surface activators of MMP-2 (gelatinase A). We have reported that MT1-MMPs and MT3-MMPs are expressed by activated vascular smooth muscle cells (SMCs) and play a role in the regulation of cell function. Overexpression of MT-MMPs results in cell rounding, decreased adherence, and increased migration. B...
متن کاملDegraded Collagen Fragments Promote Rapid Disassembly of Smooth Muscle Focal Adhesions That Correlates with Cleavage of Pp125FAK, Paxillin, and Talin
Active matrix metalloproteinases and degraded collagen are observed in disease states, such as atherosclerosis. To examine whether degraded collagen fragments have distinct effects on vascular smooth muscle cells (SMC), collagenase-digested type I collagen was added to cultured human arterial SMC. After addition of collagen fragments, adherent SMC lose their focal adhesion structures and round ...
متن کاملIntegrin cleavage regulates bidirectional signalling in vascular smooth muscle cells.
Integrins link the cytoskeleton to the extracellular matrix, providing outside-in/inside-out signalling essential for vascular smooth muscle cell (VSMC) migration in atherosclerosis. The integrin av subunit is synthesised from its precursor via furin-dependent endoproteolytic cleavage. Furin is a proprotein convertase (PC) highly expressed in VSMCs and in human atherosclerotic lesions. Inhibiti...
متن کاملI-6: Remodelling Uterine Spiral Arteries inPregnancy
Background: During the first trimester of pregnancy the uterine spiral arteries that supply blood to the placenta are remodelled, creating heavily dilated conduits lacking maternal vasomotor control. To effect permanent vasodilatation, the internal elastic lamina and medial elastic fibres must be degraded. Failure of remodelling is a key characteristic of the pathological placenta and is though...
متن کاملMechanisms of hepatocyte growth factor-mediated vascular smooth muscle cell migration.
The migration of vascular smooth muscle cells (SMCs) from the media into the neointima and their subsequent proliferation is important in the pathogenesis of atherosclerosis. This process is regulated by multiple factors, including growth factors, and involves changes in the interaction of SMCs with the extracellular matrix and in intracellular signaling cascades that regulate cell movement. We...
متن کامل